The measurement was carried out using the LogMAR scale. In all the studies, the presence of disorganization of inner retinal layers was recorded and its association with best corrected visual acuity was evaluated. In 100% of the studies, the diagnosis of diabetic macular edema in the center involved was included by spectral domain optical coherence tomography (Heidelberg). Regarding the stage of diabetes, the percentage of patients with mild nonproliferative diabetic retinopathy was 28.2%, with moderate nonproliferative diabetic retinopathy was 28.5%, with severe nonproliferative diabetic retinopathy was 15.9% and with nonproliferative diabetic retinopathy was 27.4%. In the foveal pit the only neurons are cone photoreceptors, all with slim inner segments, packed cell bodies, up to 6 layers deep reaching to the. Adapted from Cuenca, Ortuño-Lizarán and Pinilla 2018 (110). The purpose of this study was to compare ganglion. The second and third order neurons of the retinal inner nuclear and ganglion cell layers respectively are not present in the foveal pit. Regarding the population studied, 61.5% were men and 38.4% were women, most of them had diabetes mellitus type 2 (85.8%). Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. Four were retrospective, longitudinal cohort study and three cross-sectional observational. When one of them was in doubt, it was assessed by a third evaluator. All studies were evaluated by two investigators independently. Articles not published in peer review journals were excluded. References of identified studies were searched for additional relevant articles. There were no limitations regarding the type of treatment established. The studies selected for eligibility were those that included the diagnosis of diabetic macular edema (center involved, resolved), that were well documented with spectral domain optical coherence tomography, that included disorganization of inner retinal layers as one of the reported alterations, with a follow-up of at least 3 months, and those in which the best corrected visual acuity was evaluated pre and post. No restrictions were imposed on the types of study to be included. The keywords used were: “disorganization of inner retinal layers (DRIL)”, “diabetic macular edema (DME)” and “biomarkers”. A systematic search was conducted in PubMed®/MEDLINE®, Cochrane and Embase until August 2021. Disorganization of the inner retinal layers in diabeticmacular edema: systematic reviewĪBSTRACT The objective of this article was to review the disorganization of inner retinal layers as a biomarker in diabetic macular edema. Participate in a clinical research protocol. ![]() ![]() Central Serious Chorioretinopathy (CSC).
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